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Glaucoma is one of the most common causes of blindness and it is becoming even more important considering the ageing society. Because healing of died retinal nerve fibers is not possible early detection and prevention is essential. Robust, automated mass-screening will help to extend the symptom-free life of affected patients. We devised a novel, automated,(More)
Glaucoma is the second most common cause of blindness worldwide. Low awareness and high costs connected to glaucoma are reasons to improve methods of screening and therapy. A well-established method for diagnosis of glaucoma is the examination of the optic nerve head using scanning-laser-tomography. This system acquires and analyzes the surface topography(More)
Glaucoma as a neurodegeneration of the optic nerve is one of the most common causes of blindness. Because revitalization of the degenerated nerve fibers of the optic nerve is impossible early detection of the disease is essential. This can be supported by a robust and automated mass-screening. We propose a novel automated glaucoma detection system that(More)
Early detection of glaucoma is essential for preventing one of the most common causes of blindness. Our research is focused on a novel automated classification system based on image features from fundus photographs which does not depend on structure segmentation or prior expert knowledge. Our new data driven approach that needs no manual assistance achieves(More)
Glaucoma is an optic neuropathy affecting the entire visual system. The understanding of the glaucoma mechanism and causes remains unresolved. Diffusion tensor imaging (DTI) has been used to analyze the optic nerve and optic radiation showing global fiber abnormalities associated with glaucoma. Nevertheless, the complex structure of the optic radiation and(More)
OBJECTIVE Automated, objective and fast measurement of the image quality of single retinal fundus photos to allow a stable and reliable medical evaluation. METHODS The proposed technique maps diagnosis-relevant criteria inspired by diagnosis procedures based on the advise of an eye expert to quantitative and objective features related to image quality.(More)
BACKGROUND AND PURPOSE Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation. METHODS Thirty-eight young subjects (19 hypertensive and 19 normotensive) were treated with the AT1-receptor blocker candesartan cilexetil and placebo,(More)
BACKGROUND In glaucoma, damage of retinal ganglion cells may continue to the linked optic radiations. This study investigates the correlation of glaucoma severity indicators with parameters of axonal and myelin integrity of the optic radiations. METHODS In this observational case-control study, 13 patients with normal-tension glaucoma, 13 patients with(More)
Purpose of this study was to evaluate with diffusion-tensor imaging (DTI) changes of radial diffusivity (RD) and fractional anisotropy (FA) in the optic nerve (ON) and optic radiation (OR) in glaucoma and to determine whether changes in RD and FA correlate with disease severity. Therefore, glaucoma patients and controls were examined using 3T. Regions of(More)