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The halophilic γ-proteobacterium Halomonas elongata DSM 2581(T) thrives at high salinity by synthesizing and accumulating the compatible solute ectoine. Ectoine levels are highly regulated according to external salt levels but the overall picture of its metabolism and control is not well understood. Apart from its critical role in cell adaptation to(More)
The aggregation of soluble beta-amyloid (Abeta) peptide into oligomers/fibrils is one of the key pathological features in Alzheimer's disease (AD). The use of naturally occurring small molecules for inhibiting protein aggregation has recently attracted many interests due to their effectiveness for treating protein folding diseases such as AD, Parkinson's,(More)
The compatible solute ectoine protects cells from damages caused by heat, UV radiation or toxins. Ectoine is marketed in health care products and produced on a scale of tons in a biotechnological process with the halophile Halomonas elongata. The H. elongata genome was sequenced leading to the elucidation of the entire ectoine metabolism. Based on the(More)
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