Georg Geiger

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Macrophage migration inhibitory factor (MIF) binds to c-Jun activation domain binding protein-1 (JAB1)/subunit 5 of COP9 signalosome (CSN5) and modulates cell signaling and the cell cycle through JAB1. The binding domain of JAB1 responsible for binding to MIF is unknown. We hypothesized that the conserved Mpr1p Pad1p N-terminal (MPN) domain of JAB1 may(More)
Atherosclerosis is an inflammatory response of the arterial wall to "injury", which is prominently driven by cytokines. The inflammatory mediator macrophage migration inhibitory factor (MIF) is a unique cytokine that was recently associated with atherogenesis. Here, we have investigated whether MIF has a role in spontaneous atherosclerosis by studying(More)
In einer retrolektiv angelegten und prospektiv geführten Studie wird bei Frauen mit histologisch gesicherten mastopathischen Veränderungen im Alter bis zu 65 Jahren (n =1397) das absolute ipsilaterale Brustkarzinomrisiko kumulativ errechnet. Die Histologiediagnosen werden von einem in der Praxis erfahrenen Pathologen revidiert und nach der(More)
Cytostatic-induced polyneuropathy (CIPN) is a common and serious toxicity in tumor patients. Treatment and prophylactic measures are mainly ineffective. Therefore, there is an urgent need to establish a sufficient therapy for pPNP. Between July 2007 and August 2008, 20 patients were treated with low frequency (4-12 Hz) magnetic field therapy (MFT), and(More)
Ten expanded polytetrafluoroethylene (PTFE) vascular grafts were implanted in dogs crossing the joint, performed as iliofemoral bypass. After 1, 3, 6, and 9 months the grafts were studied by light microscopy, scanning, and transmission electron microscopy. There was a good patency of all straight prostheses. The pre- and postkink areas showed thrombosis(More)
In addition to the routine therapy, the patients with lateral epicondylitis included into experimental group were subjected to a 12-week cell-stimulation therapy with low-intensity frequency-modulated electric current. The control group received the same routine therapy and sham stimulation (the therapeutic apparatus was not energized). The efficiency of(More)