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OBJECTIVE To determine whether treatment with creatine can improve exercise intolerance in myophosphorylase deficiency (McArdle disease). DESIGN Double-blind, placebo-controlled crossover study with oral creatine monohydrate supplementation. PATIENTS Nine patients with biochemically and genetically proven McArdle disease were treated. INTERVENTION(More)
Multi-touch hardware has only recently entered the mainstream of information technology. Interaction designers, product developers and users have been influenced by this development. In order to build multi-touch applications, programmers have created various reusable frameworks. To obtain an overview of this diversity, we present a list of criteria to(More)
OBJECTIVE Conventional radiographic scoring methods in rheumatoid arthritis (RA) are designed to quantify progression and disregard any improvement. Reparative changes observed during longterm followup of RA have rarely been described as healing phenomena. Healing may become increasingly important with the availability of more potent antirheumatic drugs. We(More)
BACKGROUND Although the induction of irritant dermatitis by surfactants has been extensively studied in recent years, our understanding of the repair phase of irritant dermatitis is limited. OBJECTIVE We investigated qualitative and quantitative differences in surfactant-induced irritant skin reactions from short-term exposure to three structurally(More)
BACKGROUND Although surfactant-induced acute irritant dermatitis has been extensively studied, our understanding about the induction and repair of the clinically more relevant chronic form is limited. OBJECTIVE Our purpose was to investigate qualitative and quantitative differences in surfactant-induced irritant skin reactions from cumulative exposure to(More)
Radiographs of the lumbar vertebral column and sacral region obtained for 182 epileptic patients after spina bifida occulta were studied. Spina bifida occulta was twice as common in patients with idiopathic epilepsy as in those with symptomatic epilepsy and twice as common as in the normal population. A relationship between spina bifida occulta and(More)
BACKGROUND AND STUDY AIMS Regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the occurrence of colorectal adenoma and carcinoma, possibly by inducing apoptosis and/or decreasing proliferation in colorectal epithelial cells. Mesalazine is widely used in the treatment of patients with inflammatory bowel disease, and well tolerated. We(More)
Common multi-touch devices guide the user with feedback visualization during or after a registered interaction. Feed-forward techniques are less frequently used or not common at all. Our approach aims at a continuous process in which the system is aware of the users before, during, and after an explicit interaction takes place. This opens up the possibility(More)