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OBJECTIVE To determine whether treatment with creatine can improve exercise intolerance in myophosphorylase deficiency (McArdle disease). DESIGN Double-blind, placebo-controlled crossover study with oral creatine monohydrate supplementation. PATIENTS Nine patients with biochemically and genetically proven McArdle disease were treated. INTERVENTION(More)
Multi-touch hardware has only recently entered the mainstream of information technology. Interaction designers, product developers and users have been influenced by this development. In order to build multi-touch applications, programmers have created various reusable frameworks. To obtain an overview of this diversity, we present a list of criteria to(More)
BACKGROUND AND STUDY AIMS Regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the occurrence of colorectal adenoma and carcinoma, possibly by inducing apoptosis and/or decreasing proliferation in colorectal epithelial cells. Mesalazine is widely used in the treatment of patients with inflammatory bowel disease, and well tolerated. We(More)
OBJECTIVE Conventional radiographic scoring methods in rheumatoid arthritis (RA) are designed to quantify progression and disregard any improvement. Reparative changes observed during longterm followup of RA have rarely been described as healing phenomena. Healing may become increasingly important with the availability of more potent antirheumatic drugs. We(More)
Common multi-touch devices guide the user with feedback visualization during or after a registered interaction. Feed-forward techniques are less frequently used or not common at all. Our approach aims at a continuous process in which the system is aware of the users before, during, and after an explicit interaction takes place. This opens up the possibility(More)
BACKGROUND Although the induction of irritant dermatitis by surfactants has been extensively studied in recent years, our understanding of the repair phase of irritant dermatitis is limited. OBJECTIVE We investigated qualitative and quantitative differences in surfactant-induced irritant skin reactions from short-term exposure to three structurally(More)
Developing multi-touch applications is a great challenge for developers: they have to adopt a novel interaction paradigm, but lack suitable tools and reliable design guidelines. The goal of Liquid consists in introducing the concept of visual programming to multi-touch technology, implementing a promising approach to overcome the difficulties in developing(More)