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Multilayer Perceptrons (MLP, Werbos 1974, Rumelhart et al. 1986) and Radial Basis Function Networks (RBFN, Broomhead & Lowe 1988, Moody & Darken 1989) probably are the most widely used neural network models for practical applications. While the former belong to a group of " classical " neural networks (whose weighted sums are loosely inspired by biology),(More)
Conventionally, polysomnographic recordings are classified according to the rules published in 1968 by Rechtschaffen and Kales (R&K). The present paper describes an automatic classification system embedded in an e-health solution that has been developed and validated in a large database of healthy controls and sleep disturbed patients. The Somnolyzer 24x7(More)
ii iii iv v PREFACE The human species as conscious creatures seem to have something special, namely a particular organ-the brain-which can connect matter (physical entity) and mind (purely non-physical) to each other in both directions. For example, humans can assign a meaning to a physical entity; and they can also transform ideas into facts of the(More)
We propose a novel approach for building finite memory predictive models similar in spirit to variable memory length Markov models (VLMMs). The models are constructed by first transforming the n-block structure of the training sequence into a geometric structure of points in a unit hypercube, such that the longer is the common suffix shared by any two(More)
The objectives of this study were to investigate the multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual orexin receptor antagonist almorexant. Healthy subjects received daily doses of almorexant (100, 200, 400 or 1000 mg) or placebo in the morning for four days followed by two days with evening administration (Days 5-6).(More)
Quantitative analysis of sleep EEG data can provide valuable additional information in sleep research. However, analysis of data contaminated by artifacts can lead to spurious results. Thus, the first step in realizing an automatic sleep analysis system is the implementation of a reliable and valid artifact processing strategy. This strategy should include:(More)
STUDY OBJECTIVE To investigate differences between visual sleep scoring according to the classification developed by Rechtschaffen and Kales (R&K, 1968) and scoring based on the new guidelines of the American Academy of Sleep Medicine (AASM, 2007). DESIGN All-night polysomnographic recordings were scored visually according to the R&K and AASM rules by(More)
To date, the only standard for the classification of sleep-EEG recordings that has found worldwide acceptance are the rules published in 1968 by Rechtschaffen and Kales. Even though several attempts have been made to automate the classification process, so far no method has been published that has proven its validity in a study including a sufficiently(More)
The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or placebo on treatment nights at 1-week intervals. The primary(More)
Interrater variability of sleep stage scorings is a well-known phenomenon. The SIESTA project offered the opportunity to analyse interrater reliability (IRR) between experienced scorers from eight European sleep laboratories within a large sample of patients with different (sleep) disorders: depression, general anxiety disorder with and without non-organic(More)