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MOTIVATION The ability to detect copy-number variation (CNV) and loss of heterozygosity (LOH) from exome sequencing data extends the utility of this powerful approach that has mainly been used for point or small insertion/deletion detection. RESULTS We present ExomeCNV, a statistical method to detect CNV and LOH using depth-of-coverage and B-allele(More)
Interactions between the cumulus-oophorus and the oocyte have been implicated in the regulation of meiotic maturation. Quantitative analysis of freeze-fractured rat cumulus-oocyte complexes reveals that the net area of cumulus cell gap junction membrane decreases about 15-fold, 2-3 hr following an ovulatory stimulus. This dramatic loss of gap junctions is(More)
To study development, growth patterns and morphology of metastatic schwannomas in an animal model, adult Lewis rats were injected intravenously with tissue culture cells derived from a malignant schwannoma induced in a female LEW/mai rat by transplacental administration of ethylnitrosourea (ENU). Groups of animals received a single injection of 0.1 x 10(5);(More)
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