Geoffroy L. Sommen

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Synthetic organic selenium compounds, such as ebselen, may show glutathione peroxidase-like antioxidant activity and have a neurotrophic effect. We synthesized 1,3-selenazolidin-4-ones, new types of synthetic organic selenium compounds (five-member ring compounds), to study their possible applications as antioxidants or neurotrophic-like molecules. Their(More)
Aryl and alkyl isoselenocyanates 2 react with ethyl �-chloroacetoacetate (1) in the presence of triethylamine to give the corresponding 4-oxo-2-amino-4,5-dihydroselenophene-3-carboxylates 4a-f in moderate to good yields. DOI: https://doi.org/10.2174/157017807780037342 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL:(More)
We newly synthesized organic selenium compounds (5-membered ring compounds) including 2-selenoxo-1,3-thiazolidin-4-ones (compounds A) and 3-alkoxy-4,5-dihydro-5-selenoxo-1H-1,2,4-triazole-1-carboxylates (compounds B). To address whether these compounds show antioxidative effects, we also examined their superoxide radical (O(2) (-))-scavenging(More)
Treatment of �-halo alkylamines 9 and 10 with aryl and alkyl isoselenocyanates 6a–g in the presence of triethylamine in dichloromethane gave the corresponding 1,3-selenazolidines 11a–g and perhydro1,3-selenazines 12a–g, respectively, in good to excellent yields. Chemical and spectroscopic evidence for the structures of all new compounds are presented, and(More)
The reaction of phenyl isoselenocyanate (1a) with malononitrile (= propanedinitrile) in DMF in the presence of Et3N leads to the intermediate ketene N,Se-hemiacetal 6a, which can be trapped with bromoacetonitrile or a-halogenated ketones 12a and 12b (Scheme 3). The products are [(alkylseleno)(phenylamino)methylene]malononitriles 10 and 13, which are(More)
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