Geoffrey Richards

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Diverticular disease of the colon now is recognized to be functional disease resulting from altered neuromuscular activity in the colon. Inflammatory complications, when they occur, usually result from inflammation around a single diverticulum. This may lead to the formation of a pericolic or pelvic abscess. Free perforation of these leads to purulent(More)
The incidence of wound infection following surgery on the colon is reduced by the preoperative adminstration of appropriate antibiotics. Quantitative bacteriologic studies raise the fundamental question as to whether effective antibiotic prophylaxis results from reduction of the bacterial content of the gut prior to surgery or whether effective tissue(More)
Sixty Sprague-Dawley rats were pair-fed one of three nutritionally identical diets. One diet contained "low-fiber" (3.8% crude fiber); the others contained "high fiber" (28.7% crude fiber) composed of either cellulose or lignin. Although both "high fiber" diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in(More)
Metronidazole was the most effective antianaerobic agent tested in an in vitro system that used a high-density inoculum of mixed enteric organisms. A prospective randomized clinical trial assessing metronidazole and neomycin against erythromycin and neomycin as preoperative bowel preparations demonstrated a marked reduction in the anaerobic flora of(More)
Rifampin shows unique antimicrobial activity against Staphylococcus epidermidis biofilms, although in the in vitro situation rifampin resistance emerges rapidly by the selection of preexisting resistant mutants present in a small number in any large bacterial population. Fresh peritoneal dialysis solution is synergistic with rifampin suppressing rifampin(More)
The pharmacokinetic disposition of 2 g of cefoxitin administered intravenously over 30 min was determined in six patients undergoing continuous ambulatory peritoneal dialysis for chronic renal failure. During the 6-h dialysate dwell time after the drug infusion, the mean apparent volume of distribution for cefoxitin was 0.267 liter/kg (range, 0.201 to 0.325(More)
A prospective randomized clinical trial assessing the relative effectiveness of erythromycin-neomycin and metronidazole-neomycin as a preoperative bowel preparation was carried out. Bacteriologic studies of feces and colon content revealed no significant difference in the reduction of aerobic bacteria between the two groups. There was, however, a(More)
One hundred and twenty-seven rats were fed one of four diets containing graded amounts of fibre or a diet with vitamin A supplements and were given, subcutaneously, dimethyl-hydrazine or saline. Stool weight correlated directly with fibre intake and the frequency of colonic tumours decreased as fibre intake increased. An artificial fibre-free diet was also(More)