Geoffrey J. Denton

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Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display technology and gene expression systems in(More)
Aquilegia is a popular garden plant in the northern hemisphere as well as a native plant in the UK and continental Europe. In 2000, Semiaquilegia adoxoides was found infected by downy mildew in Korea, and since 2013 there have been several confirmed records of a Peronospora sp. affecting Aquilegia in the UK, with symptomatic plants being observed several(More)
MUC1 mucin is aberrantly glycosylated and overexpressed in a number of epithelial malignancies and is therefore a promising tumour-associated antigen for target-directed immunotherapy of a panel of malignant diseases. In MUC1-positive tumours, MHC class I expression is frequently downregulated and MUC1-specific cytotoxic T cells (CTLs) are either not(More)
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