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Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis.

• Emma Greig, Ray P. Boot-Handford, V. N. Deiva Mani, Geoffrey I. Sandle
• The Journal of pathology
• 2004

Impaired absorption of sodium (Na+) and water is a major factor in the pathogenesis of diarrhoea in ulcerative colitis (UC). Electrogenic Na+ absorption, present mainly in human distal colon and… (More)

Salt and water absorption in the human colon: a modern appraisal.

• Geoffrey I. Sandle
• Gut
• 1998

Characterization of apical potassium channels induced in rat distal colon during potassium adaptation.

• Ian Butterfield, Geoffrey Warhurst, M. N. Jones, Geoffrey I. Sandle
• The Journal of physiology
• 1997

1. Chronic dietary K+ loading stimulates an active K+ secretory process in rat distal colon, which involves an increase in the macroscopic apical K+ conductance of surface epithelial cells. In the… (More)

Dietary potassium modulates active potassium absorption and secretion in rat distal colon.

• Evan Foster, Geoffrey I. Sandle, John P. Hayslett, HenryJ. Binder
• The American journal of physiology
• 1986

To determine the effect of variations in body stores of potassium on the rate of active potassium transport in the large intestine, unidirectional 42K fluxes were performed under short-circuit… (More)

Cellular basis for defective electrolyte transport in inflamed human colon.

• Geoffrey I. Sandle, Naomi Higgs, Philip J Crowe, Michael N. Marsh, S. K. Venkatesan, TimJ. Peters
• Gastroenterology
• 1990

Electrolyte transport pathways in distal colonic mucosa from patients with noninflammatory and inflammatory (ulcerative colitis, Crohn's colitis) disease of the large bowel were studied in vitro with… (More)

Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis.

• Geoffrey I. Sandle, M. D. Stanton B. Perry, +4 authors Kenneth A Maclennan
• The Journal of pathology
• 2007

Decreased sodium (Na(+)), chloride (Cl(-)), and water absorption, and increased potassium (K(+)) secretion, contribute to the pathogenesis of diarrhoea in ulcerative colitis. The cellular… (More)

Enhanced large intestinal potassium permeability in end-stage renal disease.

• Thiriloganathan Mathialahan, Kenneth A Maclennan, Lance N Sandle, Caroline Sophie Verbeke, Geoffrey I. Sandle
• The Journal of pathology
• 2005

The capacity of the colon for potassium (K+) secretion increases in end-stage renal disease (ESRD), to the extent that it makes a substantial contribution to K+ homeostasis. This colonic K+ adaptive… (More)

Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.

• Geoffrey I. Sandle, John P. Hayslett, HenryJ. Binder
• Gut
• 1986

The acute effects of single pharmacological doses of glucocorticoid hormones on net electrolyte and water transport and electrical potential difference (pd) in the rectum was studied in control… (More)

Evidence for large intestinal control of potassium homoeostasis in uraemic patients undergoing long-term dialysis.

• Geoffrey I. Sandle, E Gaiger, S. M. Tapster, Timothy H. J. Goodship
• Clinical science
• 1987

1. The role of the large intestine in the maintenance of K+ balance in uraemic patients established on long-term dialysis was studied with a rectal dialysis technique in 14 normal subjects, ten… (More)

Enhanced rectal potassium secretion in chronic renal insufficiency: evidence for large intestinal potassium adaptation in man.

• Geoffrey I. Sandle, E Gaiger, S. M. Tapster, Timothy H. J. Goodship
• Clinical science
• 1986

The role of the large intestine in K+ excretion in chronic renal insufficiency was studied with a rectal dialysis technique in 14 normal subjects and eight normokalaemic, normotensive patients with… (More)

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