Geoffrey D. Carr

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Rats received injections of d-amphetamine sulphate (10 micrograms in 0.5 ul) in nucleus accumbens and were placed into one of two (randomly assigned) distinctive environments. The next day the rats were placed into the other environment and received either a saline injection or no treatment. This procedure was repeated six times. When the rats were allowed(More)
Amphetamine has rewarding properties in some behavioral paradigms, such as self-administration and conditioned place preference (CPP), but an aversive component is also apparent when the drug is tested with the conditioned taste aversion (CTA) paradigm. The persent study was an attempt to determine the neuroanatomical substrates of the drug's rewarding and(More)
Practitioners who conduct assessments of parenting capacity for the courts are faced with the challenge of determining the extent to which positive self-presentation by parents distorts test findings. This study examined positive self-presentation bias on commonly used psychological tests in cases referred following removal of children from the home because(More)
The conditioned place preference (CPP) paradigm is used widely as a measure of a drug's rewarding properties. The present study examined whether the CPP produced by amphetamine is dependent on the locomotor stimulation that is produced by the drug. An earlier study (Swerdlow and Koob 1984) found that interfering with loomotor stimulation using restraint(More)
Systemic injections of amphetamine produce both anorexia and adipsia. Evidence suggests that it is the stimulation of activity by the drug in both noradrenergic and dopaminergic synapses that mediate these effects. The present study examined the contributions of dopamine terminal regions to these effects in rats by microinjecting amphetamine directly into(More)
Although cognitive impairment is commonly associated with Parkinson's disease, the relative importance of cortical and subcortical pathologic changes to the development of dementia is controversial. Characteristic abnormalities in cortical glucose metabolism have been reported previously in Alzheimer's disease, a disease in which cortical changes(More)
Systemic injections of amphetamine result in profound changes in the behavior of animals in an open field. There is an increase in activity, certain species-typical behaviors are produced, and there is a tendency for any elicited behavior to be repeated in a stereotyped way. The present study examined the contributions of dopamine terminal regions to these(More)
The conditioned place preference method for measuring the affective properties of reinforcing events was studied using treatments of known affective value. The size of the place aversion observed increased with dose when the reinforcer was injections of lithium chloride. The size of the place preference observed increased with concentration when the(More)
Until 2003, the existing configuration of the Los Alamos Neutron Scattering Center (LANSCE) switchyard did not allow simultaneous delivery of the H<sup>&#8722;</sup>beam to Lines D and X. In the late 1990&#8217; s, with increased activities in Areas B and C, which serve the ultracold neutron experiments (UCN) and proton radiography (pRad), respectively,(More)
We performed positron emission tomography using 18F-6-fluorodopa on four Guamanians with an amyotrophic lateral sclerosis syndrome, eight Guamanians with parkinsonism, and seven clinically normal Guamanians; the results were compared with those of nine Vancouver control subjects. The Guamanian subjects had all been exposed to similar Chamorro lifestyles.(More)