Geoffrey B. Arden

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The full-field electroretinogram (ERG) is a widely used ocular electrophysiological test and we believe that a basic protocol should be standardized so that certain responses will be recorded comparably throughout the world. We propose that parameters be developed for five commonly obtained responses: 1. A response developed by the rods (in the dark-adapted(More)
Mutations in the RDS gene, which encodes the photoreceptor glycoprotein peripherin, have been sought in families with autosomal dominant retinal dystrophies. A cysteine deletion at codon 118/119 is associated with retinitis pigmentosa in one. Three families with similar macular dystrophy have mutations at codon 172, arginine being substituted by tryptophan(More)
PURPOSE To investigate the production of the voltage changes evoked in the retinal pigment epithelium (RPE) by light and alcohol and the interaction of these agents. METHODS The eye movement potential in humans was intermittently recorded to standard horizontal excursions for long periods during which either retinal illumination was altered or ethyl(More)
The retinal pigment epithelium (RPE) lying distal to the retina regulates the extracellular environment and provides metabolic support to the outer retina. RPE abnormalities are closely associated with retinal death and it has been claimed several of the most important diseases causing blindness are degenerations of the RPE. Therefore, the study of the RPE(More)
We report a method for computer enhancement of color vision tests. In our graphics system 256 colors are selected from a much larger range and displayed on a screen divided into 768 × 288 pixels. Eight-bit digital-to-analogue converters drive a high quality monitor with separate inputs to the red, green, and blue amplifiers and calibrated gun(More)
Psychophysical methods for isolating and evaluating the function of specific neural pathways are used to characterize the visual losses in patients with melanoma-associated retinopathy (MAR). These are compared with those of congenital stationary nightblindness (CSNB), a condition which displays a similar grossly abnormal ERG and loss of rod function. In(More)
This review presents a new unified view of the pathogenesis of three common causes of acquired retinal degenerative disease-diabetic retinopathy, age related macular degeneration, and retinopathy of prematurity. In these three conditions, angiogenesis has a predominant role in the development of sight threatening pathology. Angiogenesis is controlled by(More)
PURPOSE To measure changes in the relative spectral sensitivities of the dark adapted and light adapted ERG and thus to establish the possible contribution of rods to the 'blue cone' ERG elicited by flashes of blue light. BACKGROUND Short wavelength stimuli in the light-adapted eye evoke small rounded b-waves which have been considered to be S-cone(More)
AIM To provide a simple test that detects the onset of age related maculopathy (ARM), and can be used to monitor its severity. METHODS Colour contrast sensitivity was measured using computer graphics techniques. Colour thresholds were measured along tritan and protan colour confusion axes in the presence of dynamic luminance noise. Thresholds were(More)
Diabetic retinopathy (DR) is a leading cause of blindness but it is not known why retinopathy should be so early and so severe a complication of diabetes. The sensory loss caused by minute retinal lesions is part of the problem, but the diabetic changes in the brain are diVerent and less serious than in the retina, often described as an outpost of the(More)