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(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994) binds selectively and with high affinity (Ki = 0.25 nM) to neurokinin (NK)-1 tachykinin receptors in a human cell line and in guinea pigs where it acts as an antagonist as evidenced by its blockade of substance P-induced excitation of locus coeruleus neurons in vitro. Subcutaneously(More)
TRAIL (TNF (tumour necrosis factor)-related apoptosis-inducing ligand) a putative anti-cancer cytokine induces apoptosis through DISC (death-inducing signalling complex)-mediated activation of caspase-8 and/or cleavage of Bid. TRAIL is relatively specific for tumour cells but primary chronic lymphocytic leukaemia and mantle cell lymphoma (MCL) cells are(More)
INTRODUCTION AND AIMS To investigate the prevalence and nature of injecting behaviour among patients on Methadone Maintenance Treatment (MMT) programs. DESIGN AND METHODS A self-reported questionnaire was handed to 423 patients enrolled in MMT across six clinics in the lower North Island of New Zealand. RESULTS A total of 151 patients responded, giving(More)
AIM To estimate the rate of sickness presenteeism in hospital doctors in a New Zealand tertiary hospital and to also identify reasons for why doctors continue to work whilst sick. METHODS An anonymous online survey about sickness presenteeism for all hospital doctors at one tertiary care hospital in New Zealand RESULTS The response rate for the survey(More)
A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating potent D2 and 5-HT2A antagonist activity was investigated as an approach to a novel atypical antipsychotic agent. The in vitro profile of 8e from this series is a combination of D2 receptor affinity comparable to the typical antipsychotic agent haloperidol and a(More)
BACKGROUND Chronic hepatitis C (HCV) infection is an important public health issue in New Zealand, and an increasing cause of advanced liver disease. METHOD This study examined the 2015 data on hepatitis C serology in patients on opiate substitution at four Alcohol and Drug Services, as well as rates of referral and responses to treatment for HCV. (More)