Geoff A. Gross

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The heterocyclic aromatic amines (HAAs) 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) and 2-amino alpha carboline (A alpha C) were quantitated in grilled bacon and beef. The levels of PhIP in bacon ranged from < 0.1 to 52 p.p.b.,(More)
A method for screening genotoxic heterocyclic aromatic amines in cooked foods using solid-phase extraction and high-performance liquid chromatography with ultraviolet and fluorescence detection is described. Solid-phase extraction includes basic extraction on diatomaceous earth (Extrelut) and subsequent purification on propylsulphonic acid silica gel. This(More)
Historically, data fusion has focused on processing hard or physical sensor data while soft or human observed data has been neglected within fusion processes. This human observed data has much to offer towards obtaining comprehensive situational awareness, particularly in a domain such as intelligence analysis where subtle connections and interactions are(More)
In traditional data fusion hard physical sensor data has been the main source of information. This has changed during the past decade, under the backdrop of counter insurgency (COIN). In the COIN environment the majority of information comes from human sources (soft data). The source of this information can be human informants or soldiers conducting(More)
Heat-processing protein-rich foods may cause the formation of heterocyclic aromatic amines (HAAs), all of which have mutagenic and some also carcinogenic potential. Accurately measuring HAA levels in food products is therefore a necessary to realistically assess this risk factor. A solid-phase extraction method for quantitative HAA analysis has been(More)
Solid-phase extraction with the weak cation-exchange resin Fractogel TSK CM650(S) (TSK CM) was used to optimize the sensitivity and chromatographic resolution by HPLC of the mutagenic heterocyclic aromatic amines MeIQx, 4,8-DiMeIQx, IQ, MeIQ, PhIP, Trp-P-1, Trp-P-2, amino-alpha-carboline and the co-mutagens norharman and harman. The clean-up using cation(More)
Mixtures of creatinine, glucose and various single amino acids were heated at 180 degrees C for 10 min in an aqueous model system. The heated mixtures all showed mutagenic activity, ranging from 80 to 2400 TA98 revertant colonies/mumol creatinine with metabolic activation. Testing of HPLC fractions for mutagenic activity showed each mixture to contain(More)
The contribution of Phase II conjugation reactions to human disposition of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MelQx) was investigated by analysis of urine for MelQx and its sulfamate and glucuronide metabolites. Subjects consumed pan-fried fish, beef, or bacon and collected 0-12 and 12-24-h postconsumption urine samples. MelQx content of the(More)
In conventional warfare as well as counter-insurgency (COIN) operations, the understanding of the situation is extremely vital to assure a sense of security. Intelligence in COIN is about people, and deployed units in the field are the best sources of intelligence. Past and present intelligence data is analyzed to look for changes in the insurgents'(More)