• Publications
  • Influence

Claim Your Author Page
Ensure your research is discoverable on Semantic Scholar. Claiming your author page allows you to personalize the information displayed and manage publications (all current information on this profile has been aggregated automatically from publisher and metadata sources).
  • Patricio Godoy, Nicola J Hewitt, +90 authors Jan G. Hengstler
  • Medicine, Biology
  • Archives of Toxicology
  • 2013 (First Publication: 1 August 2013)
  • This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,Continue Reading
  • Nicola J Hewitt, María José Gómez Lechón, +13 authors Jan G. Hengstler
  • Biology, Medicine
  • Drug metabolism reviews
  • 2007
  • This review brings you up-to-date with the hepatocyte research on: 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk using humanContinue Reading
  • Marieke G. L. Elferink, Peter Olinga, +5 authors Geny M M Groothuis
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 2004 (First Publication: 1 November 2004)
  • Endotoxin-induced cholestasis in rodents is caused by hepatic downregulation of transporters, including the basolateral Na+-dependent taurocholate transporter (ntcp) and the canalicular bile saltContinue Reading
  • Leonie Beljaars, Grietje Molema, +5 authors Klaas Poelstra
  • Biology, Medicine
  • Hepatology
  • 1999 (First Publication: 1 May 1999)
  • The hallmark of liver fibrosis is an increased extracellular matrix deposition, caused by an activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target forContinue Reading
  • Lisa Fredriksson, Steven Wink, +9 authors Bob van de Water
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 2014 (First Publication: 1 July 2014)
  • Drug-induced liver injury (DILI) is an important clinical problem. Here, we used a genomics approach to in detail investigate the hypothesis that critical drug-induced toxicity pathways act inContinue Reading