Genta Kawaguchi

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BACKGROUND The use of a statistical approach to analyze cumulative adverse event (AE) reports has been encouraged by regulatory authorities. However, data variations affect statistical analyses (eg, signal detection). Further, differences in regulations, social issues, and health care systems can cause variations in AE data. The present study examined(More)
triisopropylsilyl group, the extent of stereocontrol was increased to 97.4:2.6. In all cases, effect of the ester group overrode the directivity of the alkoxy1 or siloxyl functionality, and the sense of the chiral delivery consistently followed eq 2. Certain aromatic substituents also affect the steric course. For example, when o-acetylbenzoic acid (1) was(More)
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