Genrikh A Tolstikov

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1. It has been established that the fragmentation of the molecular negative ions of the diacetates of sclareol and of 13-episclareol takes place with the splitting out of the fragments Ac, OAc, CH2CO, AcOH, CH3, and CH=CH2 without skeletal rearrangements. 2. The relative yields of the negative ions formed depend on the stereochemistry of the molecules of(More)
3 -Hydroxy-lup-20(29)-en-(28)-oic (betulinic) acid (I) was isolated at the beginning of the 20th century and originally called gratiolone [1]. In the past decade, some special biological properties of this triterpenoid has drawn the attention of researchers. In 1994, betulinic acid was found to exhibit anti-HIV-1 activity in H9 lymphocyte cell culture [2].(More)
In recent years, the chemical transformations and biological activity of triterpenoids of the lupane group have received much attention. It was found that betulin acylates possess antitumor properties [1], while lupeol esters with palmitic and linolic acids produce antiarrhythmic action [2]. The most promising inhibitors of HIV replication include 3-O-(3 ,3(More)
New olean-18(19)-ene triterpenoids were effectively synthesized by the interaction of allobetulin or its acetate with phosphorous oxychloride in refluxing pyridine. The structures of the synthesized 17-chloromethyloleane-18(19)-enes were confirmed by NMR spectroscopy and X-ray analysis.
It was reported that derivatives of lupane triterpenoids (lupeol, betulin, betulinic acid) exhibit antiviral activity, in particular, with respect to human immunodeficiency virus (HIV) [1], herpes simplex virus (HSV), and Epstein – Barr virus (EBV) [2 – 7]. Previously, we have also studied the anti-HIV properties of betulin 3,28-di-O-nicotinate [8] and the(More)
CIDNP techniques were applied to the investigation of the elementary mechanism of photoinduced interaction between anti-arrhythmic drug lappaconitine and amino acids tyrosine and tryptophan. It has been shown that the reactions involve the formation of lappaconitine radical anion. Lappaconitine radical anion is unstable and rapidly eliminates N-acetyl(More)
Inclusion complexes of salicylic acid (SA) and acetylsalicylic acid (aspirin, ASA) with polysaccharide arabinogalactan (AG) from larch wood Larix sibirica and Larix gmelinii were synthesized using mechanochemical technology. In the present study, we have investigated physicochemical properties of the synthesized complexes in solid state and in aqueous(More)
This study demonstrates the possibility of achieving a prophylactic effect by intramuscular injection of Abies sibirica polyprenols for the control of influenza virus infection in mice. One of the five polyprenol preparations tested, preparation N1, which had the lowest hydrophilic-lipophilic balance (8.6), produced a significant protective effect when(More)
Terpenoids of the labdane series have been extensively studied as potential drugs. In particular, forskolin and a derivative of this labdanoid were used for the treatment of glaucoma [1]. It was also reported that labdanoids showed fungistatic and antibacterial activity [2, 3], produced a cytostatic effect [4], inhibited biosynthesis of cholesterol [5],(More)