Geng Ji Zhang

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Whether membrane lipid photoperoxidation is the immediate cause for lysosomal lysis is still unclear. In this study, we investigated the direct causal factor of photoinduced lysosomal destabilization in a K+-containing solution. Methylene blue (MB)-mediated photodamage caused lysosomal membrane lipid peroxidation and loss of membrane fluidity. Compared with(More)
Isotonic K2SO4 solution protected lysosomes osmotically during a 20 min incubation, but lost its protective effect if the lysosomes were initially photooxidized after sensitization with Methylene blue. Increasing K2SO4 concentration promoted the latency loss of photodamaged lysosomes, but did not impair the integrity of unirradiated lysosomes. The results(More)
Loss of lysosomal integrity is a critical event for killing tumor cells in the photodynamic therapy of cancers. To elucidate the mechanism of photodamage induced lysosomal disintegration, we investigated the role of losing lysosomal proton translocation in latency loss of photosensitized lysosomes. Isolated rat liver lysosomes were light exposed in the(More)
The steady current field is guided by two fundamental principles, i.e., the vanishing of the curl of the field strength and the vanishing of the divergence of current density, which originate from the conservation of energy and charge, respectively. In the prevailing approach, the first principle is assumed to be generally valid and, hence, the field(More)
Changes in RNA of Baker's yeast have been studied during a thermal dehydration, through which the cellular moisture decreased from 70% to 9%, followed by a mortality of cells being less than 8%, and by consumption of the cellular glycogen. Simultaneously, the RNA of 4.2s and 5.8s increase, however, the RNA of 12.0s and 18.0s decrease during the thermal(More)
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