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p53 isoforms can regulate p53 transcriptional activity.
TLDR
It is established that p53beta can bind differentially to promoters and can enhance p53 target gene expression in a promoter-dependent manner, while Delta133p53 is dominant-negative toward full-length p53, inhibiting p53-mediated apoptosis. Expand
Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome
TLDR
In vivo validation for the gain-of-function properties of certain p53 missense mutations are provided and a mechanistic basis for these phenotypes is suggested. Expand
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
TLDR
The ability of mutant p53-R172P to induce a partial cell cycle arrest and retain chromosome stability are crucial for suppression of early onset tumorigenesis. Expand
Regulation of nucleolar signalling to p53 through NEDDylation of L11
TLDR
By controlling the correct localization and stability of L11, NEDD8 acts as a crucial, new regulator of nucleolar signalling to p53, which is required for p53 stabilization during nucleolar stress. Expand
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
TLDR
In vivo data demonstrate the importance of MDM4 independent of Mdm2 in inhibition of p53, and had a gene dosage effect, because loss of three of the four Mdm alleles also showed a more accelerated CNS phenotype than deletion of either gene alone. Expand
B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity
TLDR
It is shown that AID targets are not randomly distributed across the genome but are predominantly grouped within super-enhancers and regulatory clusters, and 3D-linked targets cooperate to recruit AID-mediated breaks. Expand
Arginine methylation controls growth regulation by E2F‐1
TLDR
It is shown that E2F‐1 is directly methylated by PRMT5, and that arginine methylation is responsible for regulating its biochemical and functional properties, which impacts on E2f‐1‐dependent growth control. Expand
p21 delays tumor onset by preservation of chromosomal stability
TLDR
P21 coupled p53-dependent checkpoint control and preservation of chromosomal stability, and cooperated with apoptosis in suppressing tumor onset in mice. Expand
miR-93 and PTEN: Key regulators of doxorubicin-resistance and EMT in breast cancer.
TLDR
The expression differences of miR-93 between paired breast cancer tissues confirmed it is involved in the progression of breast cancer, and applied the Dual-luciferase Reporter assay to expose the direct interaction between mi R-93 and PTEN suggested that miR -93 contributes to inducing EMT and drug resistance of Breast cancer cells by targeting PTEN. Expand
Metabolism‐induced tumor activator 1 (MITA1), an Energy Stress–Inducible Long Noncoding RNA, Promotes Hepatocellular Carcinoma Metastasis
TLDR
The data reveal MITA1 as a crucial driver of HCC metastasis, and highlight the identified AMPK‐MITA1‐Slug axis as a potential therapeutic strategy for HCC. Expand
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