Genevieve Wellner

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Impacts of validation design on DNA signal were explored, and the level of variation introduced by injection, capillary changes, amplification, and kit lot was surveyed by examining a set of replicate samples ranging in mass from 0.25 to 0.008 ng. The variations in peak height, heterozygous balance, dropout probabilities, and baseline noise were compared(More)
Short tandem repeat (STR) profiling from DNA samples has long been the bedrock of human identification. The laboratory process is composed of multiple procedures that include quantification, sample dilution, PCR, electrophoresis, and fragment analysis. The end product is a short tandem repeat electropherogram comprised of signal from allele, artifacts, and(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract—For forensic purposes, short tandem repeat allele signals are used as DNA fingerprints. The interpretation of signals measured from samples has traditionally been conducted by applying thresholding. More quantitative approaches(More)
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