Genevieve Fraikin

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Osteoporosis is a disease characterized by a decrease in bone mass and a deterioration in skeletal microarchitecture leading to an increased fragility and susceptibility to fracture [I]. It is now widely accepted that one of the major determinants of skeletal weakness results from the bone loss occurring after the menopause as a consequence of dramatically(More)
Over the last 10 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of(More)
The study of the effect of near-UV light (300-380 nm) on the yeast Candida guilliermondii has shown that certain doses of 313 nm light cause inactivation which is reversible after the cells have been kept for some time in a non-nutrient medium. The findings suggest a different nature of the lesions resulting in killing the cells irradiated with light of 313(More)
Certain characteristics of photoprotection induced by near-UV were studied in Candida guilliermondii. Candida tropicalis was also capable of photoprotection from the lethal effect of far-UV. The spectrum of action of photoprotection was recorded. The photoprotective effect was not found in Candida utilis. The postradiation effect of near-UV was studied. The(More)
Using a fluorescence method the interaction between serotonin and DNA has been investigated and the association constant Kc = 4.2 X 10(4) M-1 was determined. Bound serotonin is shown to reduce the yield of UV-induced thymine dimers in DNA. It is calculated that the value of the effective distance over which each protector acts is a segment of the DNA helix(More)
Dialyzed soluble proteins of Propionibacterium freudenreichii subsp. shermanii cell extract (dialyzate) were found to exert a protective and reactivating effect on Candida guilliermondii and Escherichia coli cells inactivated by UV light of C and B ranges. Reactivation occurred when dialyzate was added to irradiated bacterial suspensions immediately after(More)
Yeast Saccharomyces cerevisiae accumulate in the presence of chelator 2,2'-dipyridyl, two fractions of photosensitizer protoporphyrin IX, which fluoresce with maxima at 625 and 635 nm. The two fractions were found to differ from each other in the dynamics and character of fluorescence photobleaching. In contrast to the protoporphyrin IX that fluoresces with(More)