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About the toxicity of some Strychnos species and their alkaloids.
In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum, demonstrating good antiplasmodial activity and cytotoxic properties.
Antiplasmodial activity of alkaloids from various strychnos species.
The in vitro antiplasmodial activities of 69 alkaloids from various Strychnos species were evaluated against chloroquine-resistant and chloroquinesensitive lines of Plasmodium falciparum, and structure-activity relationships for these alkalids have begun to emerge.
In vitro screening of some Strychnos species for antiplasmodial activity.
In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja.
Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja that suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis.
In vivo antimalarial activities against the P. berghei NK173 and P. vinckei petteri murine strains were determined and it was shown that ISP was not accumulated inside the food vacuole of the parasite.