Geneva L. Henry

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The interferon-inducible protein kinase (PKR) is activated by an RNA-dependent autophosphorylation. Structure-function studies of the 551 amino acid PKR kinase from human cells have revealed that catalytic-deficient PKR mutants such as PKR(1-551)K296R display a dominant negative behavior when expressed in transfected cells. The potential for PKR to form(More)
The interferon-inducible, RNA-dependent protein kinase (PKR) is an important regulator of viral protein synthesis. Activated PKR inhibits protein synthesis by phosphorylating initiation factor eIF-2 alpha. The reovirus S4 gene, whose 1196 nucleotide mRNA transcript does not activate the PKR kinase, is efficiently expressed in vector-transfected monkey COS(More)
Web technologies offer new methods for quickly sharing and disseminating knowledge. Digital libraries of scholarly assets are proliferating online, with materials being openly licensed and shared. Sharing knowledge provides learners, instructors and researchers with access to the most recent findings, encouraging more rapid breakthroughs that lead to(More)
The Radiology Department of a leading university medical school and IBM are developing a Digital Radiology Archive (DRA) that provides a robust and highly scaleable repository for the radiology images generated by the university's existing Picture Archiving and Communications System (PACS) and relevant patient information currently maintained in the(More)
In this paper, we describe the Travelers in the Middle East Archive (TIMEA), a digital archive focused on Western explorations in the Middle East between the 18th and early 20th centuries 7. TIMEA brings together TEI-encoded texts and digital images stored in DSpace, research and teaching materials in Connexions, and GIS maps made available online through(More)