Gene V. Wallenstein

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29, 31, and 45; right 17, 35, and 37). 17. Although the improvement in WM performance with cholinergic enhancement was a nonsignificant trend in the current study (P 5 0.07), in a previous study (9) with a larger sample (n 5 13) the effect was highly significant (P , 0.001). In the current study, we analyzed RT data for six of our seven subjects because the(More)
BACKGROUND Basic science studies at the neuronal systems level have indicated that gamma-range (30-50 Hz) neural synchronization may be a key mechanism of information processing in neural networks, reflecting integration of various features of an object. Furthermore, gamma-range synchronization is thought to depend on the glutamatergically mediated(More)
The hippocampus has long been thought to be an important cortical region for associative learning and memory. After several decades of experimental and theoretical studies, a picture is emerging slowly of the generic types of learning tasks that this neural structure might be essential for solving. Recently, there have been attempts to unify(More)
A detailed biophysical model of hippocampal region CA3 was constructed to study how GABAergic modulation influences place field development and the learning and recall of sequence information. Simulations included 1,000 multicompartmental pyramidal cells, each consisting of seven intrinsic and four synaptic currents, and 200 multicompartmental interneurons,(More)
This research focuses on linking episodic memory function to the cellular physiology of hippocampal neurons, with a particular emphasis on modulatory effects at cholinergic and gamma-aminobutyric acid B receptors. Drugs which block acetylcholine receptors (e.g., scopolamine) have been shown to impair encoding of new information in humans, nonhuman primates,(More)
A model of the electrophysiological properties of rodent nucleus reticularis thalami (NRT) neurons of the dorsal lateral thalamus was developed using Hodgkin-Huxley style equations. The model incorporated voltage-dependent rate constants and kinetics obtained from recent voltage-clamp experiments in vitro. The intrinsic electroresponsivity of the model cell(More)
Spatial patterns of brain electrical activity from 61 electrodes were recorded during a sensorimotor coordination task. Subjects were required to syncopate finger movement with a series of auditory stimuli whose rate of presentation was systematically increased as a control parameter. Spontaneous transitions from syncopated to synchronized behavior were(More)
In recent years, a number of computational neural networks have been proposed aimed at describing memory functions associated with different subregions of the hippocampus, namely dentate gyrus, CA3 and CA1. Recent evidence suggests that indeed specific subregions of the hippocampus may subserve different computational functions, such as spatial and temporal(More)
Clinical and experimental observations indicate that the hippocampus is critical in the formation of declarative memories. Interestingly, electrophysiological studies have demonstrated that the region also has a particularly low seizure threshold, where globally synchronous synaptic activity can occur. By using a detailed biophysical model of area CA3, it(More)
Lesions of the dorsal hippocampus have been shown to disrupt both the acquisition and the consolidation of memories associated with contextual fear (fear of the place of conditioning), but do not affect fear conditioning to discrete cues (e.g., a tone). Blockade of central muscarinic cholinergic receptor activation results in selective acquisition deficits(More)