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T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response
Sepsis is an excessive inflammatory condition with a high mortality rate and limited prediction and therapeutic options. In this study, for the first time, to our knowledge, we found thatExpand
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Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis.
PURPOSE The aims of this study were to determine whether IL-17(+) T cells were present in CD4 and CD8 interphotoreceptor retinoid-binding protein (IRBP)-specific T cells and to determine the role ofExpand
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Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells
Although human and bovine gammadelta T cells were shown to express MHC class II antigen and function as APCs, attempts to determine if mouse gammabeta T cells have similar functions remainedExpand
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The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.
By binding to T cell Ig mucin-3 (Tim-3) expressed on different cells, galectin-9 (Gal-9) mediates two important functions, triggering T cell death and activating innate immune cells. The mechanismsExpand
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Critical role for thymic CD19+CD5+CD1dhiIL‐10+ regulatory B cells in immune homeostasis
This study tested the hypothesis that besides the spleen, LNs, peripheral blood, and thymus contain a regulatory IL‐10‐producing CD19+CD5+CD1dhigh B cell subset that may play a critical role in theExpand
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Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive.
  • Y. Peng, H. Shao, +4 authors D. Sun
  • Medicine, Biology
  • Investigative ophthalmology & visual science
  • 1 May 2007
PURPOSE Results in previous reports have demonstrated that immunization of the EAU-prone B6 mouse activates both CD4 and CD8 IRBP-specific T cells. The purpose of this study was to investigateExpand
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BAFF Suppresses IL-15 Expression in B Cells
Clinical trials have shown that BAFF inhibitors do not reduce memory B cell levels but can reduce the number of mature B cells. It remains uncertain whether BAFF affects memory-maintaining cytokinesExpand
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Suppressor role of rat CD8+CD45RClow T cells in experimental autoimmune uveitis (EAU)
To determine whether decreased regulatory T cell activity contributes to the pathogenesis of recurrent experimental autoimmune uveitis (EAU), we compared the immunoregulatory activity ofExpand
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GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.
BACKGROUND Our previous studies have demonstrated that GAD-IgG-transduced splenocytes protect non-obese diabetic (NOD) mice from diabetes by in vitro-inducing CD4(+)Foxp3(+)Treg cells. However, theExpand
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Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis
Regulatory IL-10-producing CD1dhighCD5+CD19+ B cells and CD4+CD25+Foxp3+ T cells have been found to modulate immune responses in autoimmunity, infection, and cancer, but the interaction between theseExpand
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