Gen Yang

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BACKGROUND Cancer stem cells (CSCs) paradigm suggests that CSCs might have important clinical implications in cancer therapy. Previously, we reported that accumulation efficiency of CSCs is different post low- and high-LET irradiation in 48 h. METHODS Cancer stem cells and non-stem cancer cells (NSCCs) were sorted and functionally identified through a(More)
We introduced the gene for wild-type human p53 or p21, a critical downstream mediator of p53-induced growth suppression, into a p53-deficient mouse prostate cancer cell line using a recombinant adenoviral vector (Ad5CMV-p53 or Ad5CMV-p21). Elevated levels of endogenous mouse p21 mRNA provided evidence for the functional activity of virally transduced p53.(More)
Tumors are often heterogeneous in which tumor cells of different phenotypes have distinct properties. For scientific and clinical interests, it is of fundamental importance to understand their properties and the dynamic variations among different phenotypes, specifically under radio- and/or chemo-therapy. Currently there are two controversial models(More)
Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome(More)
The geometric locations of ion traversals in mammalian cells constitute important information in the study of heavy ion-induced biological effect. Single ion traversal through a cellular nucleus produces complex and massive DNA damage at a nanometer level, leading to cell inactivation, mutations and transformation. We present a novel approach that uses a(More)
Binary decomposition techniques transform a multi-class problem into several simpler binary problems. In such techniques , a classical issue is to ensure the consistency between the binary assessments of conditional probabilities. Nested dichotomies , which consider tree-shaped decomposition , do not suffer from this issue. Yet , a wrong probability(More)
(2016). Comparison of whole-exome sequencing of matched fresh and formalin fixed paraffin embedded melanoma tumours: implications for clinical decision making. (2015). Accuracy of self-reported nevus and pigmentation phenotype compared with clinical assessment in a population-based study of young Australian Adults. A. (2015). Clinical practice guidelines(More)
Tumor cells often exist in different phenotypes with distinct properties. Ever-increasing evidence strongly supported the existence of the cancer stem cells (CSCs) and non-stem cancer cells (NSCCs) in various tumors. It is of fundamental importance to understand the properties of the phenotypes under radiation and chemical treatments, for CSCs are regarded(More)