Gen-Lin Li

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AIM To determine the location of c-jun protein, dynamic changes in c-jun mRNA and protein expression, and ultrastructure characteristics in the rd mouse retina, following a single dose of brain-derived neurotrophic factor (BDNF) in a short period of time. METHODS A single intravitreal injection of BDNF at two dosages (25µg/L or 50µg/L) was given to the(More)
OBJECTIVE To study possible protective effects of extract of Lycium barbarum L. on the cultured human retinal nerve cells. METHODS Retinal nerve cells were co-cultured with the extract of Lycium barbarum L. and 24 hours and 72 hours later, retinal nerve cells were respectively used to evaluate cell proliferation with MTT assays; to observe ultracellular(More)
Recently, many studies indicated that certain medications can delay the apoptosis of retinal nerve cells at different points during the process of apoptosis and have neuroprotective effect on preventing degenerative ocular fundus diseases. N-methyl-D-aspartate receptor (NMDAR) antagonists, NMDAR-associated calcium channel blockers and acetylcholine receptor(More)
OBJECTIVE To select the optimum extraction process of Zhanjin Ruji. METHOD To observe influence of extraction time upon the extraction rate of volatile oil, the orthogonal test was adopted to observe the extraction process by alcohol from the extraction rate and content of the total saponins in Radix Notoginseng. RESULT The three kinds of herbs(More)
Several studies have investigated the protective functions of brain-derived neurotrophic factor (BDNF) in retinitis pigmentosa. However, a BDNF-based therapy for retinitis pigmentosa is not yet available. To develop an efficient treatment for fundus disease, an eukaryotic expression plasmid was generated and used to transfect human 293T cells to assess the(More)
The role of cytokines in retinal functional reconstruction has been studied extensively. It has been found that brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), basic fibroblast growth factor (bFGF) and neurotrophin-4 (NT-4) can not only prevent retinal photoreceptor cells (RPCs) from degeneration and improve RPCs recovery after(More)
OBJECTIVE To explore the possible mechanism of ferulic acid (FA) on the proliferation of nerve cells of retinas in vitro and provide the principal for prevention and treatment of some degenerative retinal diseases. METHODS Retinal cells suspension from 7 months human embryo, neonatal calf, and 4 months postnatal mice were treated with FA, brain-derived(More)
It has been found that various extracellular matrix (ECM) probably play an important role in the occurrence of proliferative vitreoretinopathy (PVR), including structural proteins, adhesive proteins, anti-adhesive proteins, matrix metalloproteinase (MMP), and tissue inhibitor of MMP (TIMP) Structural proteins, including collagen and elastic fiber family,(More)