Community infections caused by extended-spectrum beta-lactamase-producing Escherichia coli.
- J. Rodríguez-Baño, J. Alcalá, Á. Pascual
- Medicine, BiologyArchives of Internal Medicine
- 22 September 2008
Fosfomycin and amoxicillin-clavulanate appear to be effective for cystitis caused by susceptible isolates, and in predisposed patients, ESBL-producing E coli is a notable cause of community-acquired infection, and particularly UTI.
Detection of heteromerization of more than two proteins by sequential BRET-FRET
- P. Carriba, Gemma Navarro, R. Franco
- BiologyNature Methods
- 2 July 2008
Using SRET, complexes of cannabinoid CB1, dopamine D2 and adenosine A2A receptors in living cells are identified and will allow us to better understand how signals are integrated at the molecular level.
Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis.
- J. Rodríguez-Baño, E. Picón, Á. Pascual
- Medicine, BiologyClinical Infectious Diseases
- 2010
Clinicians should consider adequate empirical therapy with coverage of these pathogens for patients with risk factors, including ESBLEC, which is an important cause of COBSI due to E. coli.
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
- J. Bonaventura, Gemma Navarro, V. Casadó
- Biology, ChemistryProceedings of the National Academy of Sciences
- 22 June 2015
Novel unsuspected allosteric mechanisms within the heteromer are described by which not only A2AR agonists, but also A2 AR antagonists, decrease the affinity and intrinsic efficacy of D2R agonists and the affinity of D1R antagonists.
Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers*
- Gemma Navarro, S. Ferré, A. Woods
- Biology, ChemistryJournal of Biological Chemistry
- 18 June 2010
Analysis of MAPK signaling in striatal slices of CB1 receptor KO mice and wild-type littermates supported the existence of A1-CB1-D2 receptor heteromer in the brain and allowed the first molecular model of the quaternary structure of a receptor heteromultimer to be proposed.
Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine
- Gemma Navarro, E. Moreno, R. Franco
- Biology, PsychologyProceedings of the National Academy of Sciences
- 18 October 2010
The results provide a molecular explanation for which D1R plays a more significant role in the behavioral effects of cocaine, through σ1R-D1R heteromerization, and provide a unique perspective toward understanding the molecular basis of cocaine addiction.
Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors
- E. Martínez-Pinilla, K. Varani, R. Franco
- Biology, ChemistryFrontiers in Pharmacology
- 23 October 2017
It is confirmed that CBD does not bind with high affinity to the orthosteric site of the human CB2R where the synthetic cannabinoid, [3H]-WIN 55,212-2, binds, and CBD was, however, able to produce minor but consistent reduction in the homogeneous binding assays in living cells using the fluorophore-conjugatedCB2R-selective compound, CM-157.
Validation of the Spanish version of the Lawton IADL Scale for its application in elderly people
- I. Vergara, A. Bilbao, M. Orive, S. García-Gutiérrez, Gemma Navarro, J. Quintana
- Psychology, MedicineHealth and Quality of Life Outcomes
- 30 October 2012
The results confirm that the Spanish version of the Lawton IADL Scale has excellent reliability and validity and a moderate to large sensitivity to change.
Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2A G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer
- Gemma Navarro, P. Carriba, R. Franco
- Biology, ChemistryTheScientificWorldJournal
- 11 October 2008
A combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.
The Minnesota living with heart failure questionnaire: comparison of different factor structures
- A. Bilbao, A. Escobar, L. García-Pérez, Gemma Navarro, R. Quirós
- Psychology, MedicineHealth and Quality of Life Outcomes
- 17 February 2016
The results support the validity of using the MLHFQ physical, emotional and total scores in patients with HF, for clinical practice and research, and recommend the use of Munyombwe’s social factor.
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