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Various studies suggest that Hedgehog (Hh) signalling plays roles in human and zebrafish ocular development. Recent studies (Kerr et al., Invest Ophthalmol Vis Sci. 2012; 53, 3316-30) showed that conditionally activating Hh signals promotes murine lens epithelial cell proliferation and disrupts fibre differentiation. In this study we examined the expression(More)
While photoreceptor loss is the most devastating result of inherited retinal degenerations such as retinitis pigmentosa, inner retinal neurons also undergo significant alteration. Detailing these changes has become important as many vision restorative therapies target the remaining neurons. In this study, the rd1-Fos-Tau-LacZ (rd1-FTL) mouse model was used(More)
Although many of the molecular interactions in kidney development are now well understood, the molecules involved in the specification of the metanephric mesenchyme from surrounding intermediate mesoderm and, hence, the formation of the renal progenitor population are poorly characterized. In this study, cDNA microarrays were used to identify genes enriched(More)
PURPOSE Previous studies indicate that the Wnt/beta-catenin-signaling pathway is active and functional during murine lens development. In this study, the consequences of constitutively activating the pathway in lens during development were investigated. METHODS To activate Wnt/beta-catenin signaling, beta-catenin (Catnb) and adenomatous polyposis coli(More)
In the past twenty years much efforts have been devoted to the development of ontologies and term bases for different fields. All this work has been done separately or with slight integration. The GENOMA-KB is a project whose main aim is to integrate, at least, both resources. In this paper, most relevant aspects of the project are presented. Each module is(More)
BACKGROUND A disintegrin and metalloproteinase with thrombospondin motifs 1, Adamts-1, is important for the development and function of the kidney. Mice lacking this protein present with renal lesions comprising enlarged calyces, and reduced cortex and medulla layers. Our current findings are consistent with the defect occurring due to a developmental(More)
This paper presents the analysis done by the API-Uniovi group to the problem of load forecasting in Slovakia in January 1999. Due to the available data, the predictor is designed after a decomposition of the different variables of influence. In general, patterns of demand behavior are modeled with Unsu-pervised Kohonen Neural Networks and forecasting is(More)
EU Kids Online is a network funded by the EC Safer Internet plus Programme It examines research carried out in 21 member states into how children and young people use the internet and new media. This three-year collaboration aims to identify comparable research findings across Europe and to evaluate the social, cultural and regulatory influences affecting(More)
This paper presents the analysis done by a group of researchers from University of Oviedo in order to afford the problem presented in the classification of blind bank data in the framework of the EUNITE 2002 competition. Due to the available data, the predictor is designed after a decomposition of the different variables of influence. In general, a first(More)
One of the main problems in transmission electron microscopy in the biological field is the tri-dimensionality. This article explains the technical procedures and requirements to prepare biological specimens preserving them closest to their native state to perform 3D reconstruction of the macromolecular complexes and cellular structures in their natural(More)