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An organotrifluoroborate for broadly applicable one-step 18F-labeling.

• Zhibo Liu, Maral Pourghiasian, +7 authors David M Perrin
• Angewandte Chemie
• 2014

A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford undergo facile bioconjugation to several clinically relevant peptides and one enzyme inhibitor. Molecularly… (More)

p-NO2-Bn-H4neunpa and H4neunpa-Trastuzumab: Bifunctional Chelator for Radiometalpharmaceuticals and 111In Immuno-Single Photon Emission Computed Tomography Imaging.

• Sarah Spreckelmeyer, Caterina F Ramogida, +10 authors Chris Orvig
• Bioconjugate chemistry
• 2017

Potentially nonadentate (N5O4) bifunctional chelator p-SCN-Bn-H4neunpa and its immunoconjugate H4neunpa-trastuzumab for 111In radiolabeling are synthesized. The ability of p-SCN-Bn-H4neunpa and… (More)

Design, synthesis and evaluation of novel bifunctional tetrahydroxamate chelators for PET imaging of 89Zr-labeled antibodies.

• Julie Anne Rousseau, Zhengxing Zhang, +4 authors Kuo-Shyan Lin
• Bioorganic & medicinal chemistry letters
• 2017

Two compact and symmetrical bifunctional tetrahydroxamate chelators, 1 and 2, were synthesized and evaluated for labeling antibodies with 89Zr for imaging with positron emission tomography. Using… (More)

89Zr for antibody labeling and in vivo studies - A comparison between liquid and solid target production.

• Gemma M Dias, Caterina F Ramogida, +5 authors François Bénard
• Nuclear medicine and biology
• 2018

INTRODUCTION Zirconium-89 (89Zr, t1/2=78.4h) liquid target (LT) production offers an approach to introduce this positron-emitting isotope to cyclotron centres without the need for a separate solid… (More)

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