Gemma C. Nassta

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Oxytocin is recommended by the World Health Organisation as the most effective uterotonic for the prevention and treatment of postpartum haemorrhage. The requirement for parenteral administration by trained healthcare providers and the need for the drug solution to be maintained under cold-chain storage limit the use of oxytocin in the developing world. In(More)
Chemogenomics methods seek to characterize the interaction between drugs and biological systems and are an important guide for the selection of screening compounds. The acid/base character of drugs has a profound influence on their affinity for the receptor, on their absorption, distribution, metabolism, excretion and toxicity (ADMET) profile and the way(More)
n engl j med 368;22 nejm.org may 30, 2013 2145 The Authors Reply: The randomized trials mentioned by Van Schooneveld et al. reporting higher cure rates for vancomycin included patients with a first infection or first recurrence of C. difficile infection.1,2 Most of the patients in our study had their fourth episode before study inclusion, which explains the(More)
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