OBJECTIVE The objective of the following study is to assess parent reported quality of life (QOL) in children with epilepsy and to assess the demographic and clinical factors, which influence the QOL in children with epilepsy. STUDY PARTICIPANTS We consecutively enrolled 40 children aged from 2 years to 14 years with active epilepsy who had undergone a… (More)
Introduction: Hallervorden-Spatz syndrome, now known as pantothenate kinase-associated neurodegeneration (PKAN), is an autosomal recessive disorder causing progressive extrapy-ramidal dysfunction and dementia. It is characterized by progressive degeneration of basal ganglia, globus pallidus and reticular part of the substantianigra, produced by iron… (More)
Delayed neuronal death following hypoxic ischaemic insult is primarily mediated by the N-methyl D-aspartate (NMDA) receptor. The NMDA receptor antagonist MK 801, has been shown to limit neuronal death following hypoxic ischaemic injury but is too toxic to be used in the human neonate. Magnesium blocks the NMDA channel in a voltage dependent manner. Its… (More)
BACKGROUND Magnesium ion gates the N-methyl-D-aspartate (NMDA) receptor and may protect the brain from NMDA receptor-mediated asphyxial injury. The present study evaluated the neuroprotective role of magnesium in birth asphyxia. MATERIAL AND METHODS Forty term neonates with severe birth asphyxia were randomized to either the study group or the control… (More)
OBJECTIVE To evaluate the safety and efficacy of three benzodiazepine drugs: Lorazepam, Midazolam and Diazepam, when given parenterally in the control of acute seizure. METHODS One hundred and twenty children of either sex in the age group 6 month to 14 years brought convulsing to the pediatric emergency services, were enrolled in the study. These were… (More)
OBJECTIVE To study acid-base imbalance in common pediatric diseases (such as sepsis, bronchopneumonia, diarrhea, birth-asphyxia etc.) in neonates. DESIGN AND SETTING An observational study was conducted in an emergency room of a tertiary teaching care hospital in Haryana, India. PATIENTS AND METHODS Fifty neonates (from first hour to one month)… (More)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. In addition to the three classical SMA types, a new form known as type 0 with intrauterine onset, profound hypotonia and a progressive and… (More)
Multicystic dysplastic kidney (MCDK) is the most common form of renal cystic disease in children and is one of the most common causes of abdominal mass in infancy. Here in we are reporting a rare case of a large MCKD that caused respiratory compromise and the infant presented with respiratory distress.
CONTEXT Children with recurrent wheezing contribute to a significant burden of inpatient hospital admission in developing countries. However, many patients could be managed at home following a short observation period in emergency unit. AIM This study aimed to determine the predictors of critical care admission in a population of children aged 6 months to… (More)
Congenital isolated pleural effusion is a rare cause of respiratory distress in neonates. It is usually chylous. Herein, we report a rare case of nonchylous congenital idiopathic pleural effusion.