Geertruy Te Kronnié

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One of the biggest challenges in tumour research is the possibility to reprogram cancer cells towards less aggressive phenotypes. In this study, we reprogrammed primary Glioblastoma multiforme (GBM)-derived cells towards a more differentiated and less oncogenic phenotype by activating the Wnt pathway in a hypoxic microenvironment. Hypoxia usually correlates(More)
Vertebrate CASK is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. CASK is present in the nervous system where it binds to neurexin, a transmembrane protein localized in the presynaptic membrane. The Drosophila homologue of CASK is CAKI or CAMGUK. CAKI is expressed in the nervous system of larvae and adult flies. In adult(More)
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of(More)
Canine Diffuse Large B-cell Lymphoma (cDLBCL) is an aggressive cancer with variable clinical response. Despite recent attempts by gene expression profiling to identify the dog as a potential animal model for human DLBCL, this tumor remains biologically heterogeneous with no prognostic biomarkers to predict prognosis. The aim of this work was to identify(More)
Vertebrate CASK is a member of the MAGUK family of proteins. CASK is present in the nervous system where it binds to NEUREXIN, a transmembrane protein localized in the pre-synaptic membrane. The Drosophila homolog of CASK is CAKI or CAMGUK. CAKI is expressed in the nervous system of larvae and adult flies. In adult flies the expression of caki is(More)
  • Falzacappa Mv, Ronchini C, Faretta M, Iacobucci I Di, Rora Ag, Martinelli G +82 others
  • 2015
Central nervous system acute lymphoblastic leukemia: role of natural killer cells. Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model. Impact of genomic damage and ageing on stem cell function. 9. Heigele A, Camerini D, van't Wout AB, Kirchhoff F. Viremic long-term nonprogressive HIV-1 infection is(More)
In the axial musculature of adult fish two major populations of muscle fibres lay anatomically separated: 1) a triangular red zone at the level of the horizontal septum composed of red fibres and 2) the largest part of the myotome that is filled with the white muscle bulk. The first locomotion of newly hatched fish larvae is probably powered by the red(More)
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