Gayle P Pouliot

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This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two types of cancer-specific nuclear bodies, caused by locus-specific deregulation of HSATII. DNA demethylation at the 1q12(More)
1096 volume 20 | number 10 | october 2014 nature medicine thymocyte-specific Myc inactivation10. Notably, other tissues whose development is dependent on physiologic NOTCH1 activity, such as skin and intestine, were unaffected in NMe–deficient mice, suggesting that this enhancer has unique roles in the T cell lineage. The authors then investigated the role(More)
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