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Myosin 5a is a dual-headed molecular motor that transports cargo along actin filaments. By following the motion of individual heads with interferometric scattering microscopy at nm spatial and ms temporal precision we found that the detached head occupies a loosely fixed position to one side of actin from which it rebinds in a controlled manner while(More)
Computer-aided Design for Manufacturing (DFM) systems play an important role in reducing the time taken for product development by providing manufacturability feedback to the designer while a particular component is being designed. Traditionally, DFM rules are hand-crafted and used to accelerate the engineering product design process by integrating(More)
Deep 3D Convolutional Neural Networks (3D-CNN) are traditionally used for object recognition, video data analyt-ics and human gesture recognition. In this paper, we present a novel application of 3D-CNNs in understanding difficult-to-manufacture features from computer-aided design (CAD) models to develop a decision support tool for cyber-enabled(More)
QUESTION: In pregnant women with a fear of vaginal delivery, is intensive treatment more effective than conventional treatment for reducing requests for caesarean section? Design Randomised {allocation not concealed*} †, blinded {cli-nicians and data analysts} †,* controlled trial with follow up 3 months postpartum. Patients 176 pregnant women referred for(More)
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