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  • Bharat Bhushan Aggarwal, Gautam Sethi, +5 authors Haruyo Ichikawa
  • Medicine, Biology
  • Annals of the New York Academy of Sciences
  • 2006 (First Publication: 1 December 2006)
  • Recent evidence indicates a convergence of molecular targets for both prevention and therapy of cancer. Signal-transducer-and-activator-of-transcription-3 (STAT3), a member of a family of sixExpand
  • Sarah A. Caldwell, Stephanie R. Jackson, +5 authors Mauricio J Reginato
  • Biology, Medicine
  • Oncogene
  • 2010 (First Publication: 13 May 2010)
  • Cancer cells upregulate glycolysis, increasing glucose uptake to meet energy needs. A small fraction of a cell's glucose enters the hexosamine biosynthetic pathway (HBP), which regulates levels ofExpand
  • Gautam Sethi, Kwang Seok Ahn, Bharat Bhushan Aggarwal
  • Medicine, Biology
  • Molecular Cancer Research
  • 2008 (First Publication: 1 June 2008)
  • Thymoquinone (TQ), derived from the medicinal plant Nigella sativa, exhibits antiinflammatory and anticancer activities through mechanism(s) that is not fully understood. Because numerous effectsExpand
  • Aman P. Mann, Amit Verma, +7 authors Kapil Mehta
  • Biology, Medicine
  • Cancer research
  • 2006 (First Publication: 1 September 2006)
  • The transcription factor nuclear factor-kappaB (NF-kappaB) plays an important role in regulating cell growth, apoptosis, and metastatic functions. Constitutive activation of NF-kappaB has beenExpand
  • Kwang Seok Ahn, Gautam Sethi, Koyamangalath Krishnan, Bharat Bhushan Aggarwal
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2007 (First Publication: 5 January 2007)
  • Unlike the tocopherols, the tocotrienols, also members of the vitamin E family, have an unsaturated isoprenoid side chain. In contrast to extensive studies on tocopherol, very little is known aboutExpand
  • Santosh Kumar Sandur, Manoj Kumar Pandey, +6 authors Bharat Bhushan Aggarwal
  • Medicine, Biology
  • Carcinogenesis
  • 2007 (First Publication: 1 August 2007)
  • Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (Cur), such as demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC),Expand