Gaurav Gandhi

Learn More
We describe a drug delivery method that combines Time-Reversal Acoustics (TRA) with Convection-Enhanced Delivery (CED) to improve the delivery of therapeutics to the interstitium of the brain. The Ultrasound-assisted CED approach (UCED) circumvents the blood-brain barrier by infusing compounds through a cannula that is inserted into the brain while(More)
Our purpose is to improve the performance sensitivity of a fiber sensor used as a fiber optic hydrophone probe (FOHP) by the addition of nanoscale thin film gold coating. The fiber is designed to provide a uniform and spatial averaging free response up to 100 MHz by etching down to an active diameter of approximately 9 mum. The performance sensitivity of(More)
BACKGROUND Previously we reported that the variable outer membrane lipoprotein Vsp1 from the relapsing fever spirochete Borrelia turicatae disseminates from blood to brain better than the closely related Vsp2 [1]. Here we studied the interaction between Vsp1 and Vsp2 with brain endothelium in more detail. METHODOLOGY/PRINCIPAL FINDINGS We compared Vsp1 to(More)
In this paper, a novel approach of using genetic algorithm towards realization of Chua’s circuit is presented. The paper demonstrates the use of genetic algorithm to evolve Chua’s circuit from a set of given passive and active components. More than a dozen of the evolved designs are demonstrated to work satisfactorily in simulation. The evolved designs are(More)
A plug-n-play internet enabled platform for real time simulation of image processing algorithms (like CNN) is demonstrated on the Bit by Bit platform. The prototyping platform uses Raspberry Pi, thereby enabling collaboration and sharing of the image processing simulation experiments and results over the internet. These algorithms can be applied to the real(More)
This dissertation (i) describes parallel histogram modification techniques with embedded morphological preprocessing methods within the CNN-UM framework, describes and illustrates how the implementation of the algorithm results in an adaptive multi-thresholding scheme when histogram modification is combined with embedded morphological processing at a finite(More)
This work considers the need for both the amplitude and phase to fully characterize polyvinylidene fluoride (PVDF) membrane hydrophones and presents a comprehensive discussion of the nonlinear acoustic measurements utilized to extract the phase information and the experimental results taken with two widely used PVDF membrane hydrophones up to 100 MHz. A(More)