Gaurav Das

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An ideal nano drug delivery agent must be potent enough to carry high dose of therapeutics and competent enough in targeting specific cell of interest, having adequate optimized physiochemical properties and biocompatibility. Carrying differentially polar therapeutics simultaneously will make them superior in their class. However, it is of enormous(More)
Factors associated with conidial germination and appressoria formation ofGlomerella cingulata causing the brown blight disease of tea (Camellia sinensis) were studiedin vitro. Spore germination and appressoria formation were optimum at a temperature of 25°C, pH 5.0, 7 h light/day regime and a 24-h incubation period. At a concentration of conidia of 1200/μL(More)
A tumor-like multi-cellular spheroid (3D) differs from a 2D cell in a number of ways. This is demonstrated using time resolved confocal microscopy. Two different tumor spheroids - HeLa (cervical cancer) and A549 (lung cancer) - are studied using 3 different fluorescent dyes - C153 (non-covalent), CPM (covalent) and doxorubicin (non-covalent, anti-cancer(More)
A novel neuro-compatible peptide-based hydrogel has been designed and developed, which contains microtubule stabilizing and neuroprotective short peptide. This hydrogel shows strong three-dimensional cross-linked fibrillary networks, which can capture water molecules. Interestingly, this hydrogel serves as excellent biocompatible soft material for 2D and 3D(More)
Microtubules regulate eukaryotic cell functions, which have tremendous implication in tumor progression. Thus, the design of novel approaches for controlling microtubule function is extremely important. In this manuscript, a novel tetrapeptide Ser-Leu-Arg-Pro (SLRP) has been designed and synthesized from a small peptide library consisting of 14(More)
Many anticancer drugs are developed for the treatment of cancer from natural sources. Photosystem I (PSI), a protein complex present in the chloroplast, is involved in photosynthesis and generates reactive oxygen species (ROS) in plant. Here, we used the ROS generation property of PSI for cancer therapy. We show that PSI can enter into different kinds of(More)
The SAFT−FMT−DFT approach to adsorption equilibrium combines elements of the statistical associating fluid theory (SAFT), fundamental measure theory (FMT), and classical density functional theory (DFT) to create a framework to model fluids described as chain molecules in the presence of external fields. In this paper, the SAFT−FMT−DFT approach is used to(More)
The vapor pressure of four liquid perfluoroalkylalkanes (CF3(CF2)n(CH2)mCH3; n = 3, m = 4,5,7; n = 5, m = 5) was measured as a function of temperature between 278 and 328 K. Molar enthalpies of vaporization were calculated from the experimental data, and the results were compared with data from the literature for the corresponding alkanes and(More)
An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the(More)
Zeolite was synthesised from fly ash collected from a power plant of Neyveli Corporation, Chennai, India. The synthesised zeolite was characterized using SEM, XRD, and FT-IR. Experiments were conducted to determine the feasibility of using the synthesized zeolite for the adsorption of cadmium using batch technique. The effect of time, dosage, temperature(More)