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On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency.
A technique for electrophoretic analysis of the hemoglobin mixtures from single erythrocytes has been developed. Hemoglobin mixtures were separated into their constituents, A(2), A, C, S, and J, at least qualitatively.
A mechanism for converting human chromatid 17 into its isoforms-isochromatid 17q and isochromosome X17q--is discussed. The frequency of these isoforms in a subset of Ph+ chronic myeloid leukemia patients is traceable to singularities of the nuclear envelope of myeloid cells. When statistically interpreted, loss of tumor suppressor gene (p53) seems less… (More)
After developing a map for certain states typical of hemopoietic stem cells (SCs), we identify a number of parameters (e.g. fractal dimensions, oscillatory behavior in a multistable landscape, etc.) that scale down to subcellular structures such as interphase genome, chromatids, chromatin entanglements and DNA segmental motions. A curious aspect is the… (More)
Logical scrutiny of the axiom of randomness argues against its reliability as an objective criterion for interpreting the insurgence of mutations in cancer cells. We propose that chaos theory is preferable because it is conceptually much more robust.