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Preparation and antitrypanosomal activity of secochiliolide acid derivatives.
The results indicate that the carboxyl group is not essential for the bioactivity of 1, while the presence of the tetrasubstituted exocyclic double bond seems to be important.
Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities
One of the new hydroquinones showed promising results against the human pancreatic ductal carcinoma cell line PANC1, with similar cytotoxic activity as the commercial chemotherapy drug doxorubicin.
Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei
Results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against L. fortunei.
Metabolites from the Dark Septate Endophyte Drechslera sp. Evaluation by LC/MS and Principal Component Analysis of Culture Extracts with Histone Deacetylase Inhibitors
Secondary metabolites from the cultures of the dark septate fungal endophyte (DSE) Drechslera sp., isolated from the roots of rye grass (Lollium sp.) and cultured under different experimental
Cytotoxic terpenoids from Nardophyllum bryoides.
The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids, four of which are hitherto unknown and several showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line.
Dolabellane Diterpenoids from the South Atlantic Gorgonian Convexella magelhaenica.
Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in
Isolation of acetylated bile acids from the sponge Siphonochalina fortis and DNA damage evaluation by the comet assay
A possible role of acetylated bile acids as a chemical defense mechanism, product of a symbiotic relationship with microorganisms, which would explain their seasonal and geographical variation, and their influence on the previously observed genotoxicity of the organic extract of S. fortis is suggested.
Lanostanoid triterpenes from the fungus Rigidoporus microporus
Five new lanostanoid triterpenes were isolated from the extract of R. microporus and evaluated for their antifungal activity and the bioactivity as agonist/antagonists of the liver X receptors (LXRs).
Evaluation of in vitro Antifungal Activity of Xylosma prockia (Turcz.) Turcz. (Salicaceae) Leaves Against Cryptococcus spp.
In vitro anticryptococcal effects of the leaf ethanolic extract of X. prockia leaf extract might indeed be a potential source of antifungal agents are evaluated and demonstrated that EAF was more selective for yeasts than was PBMCs.
Study of metal complexation of cardenolides with divalent metal ions by Electrospray Ionization Mass Spectrometry
Abstract Cardenolides are natural products with positive inotropic and cytotoxic activity that are able to interact with metals, although the possible role that these interactions may play in their