Gastão F. Miranda

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The Local Riemannian Manifold Learning (LRML) recovers the manifold topology and geometry behind database samples through normal coordinate neighborhoods computed by the exponential map. Besides, LRML uses barycentric coordinates to go from the parameter space to the Riemannian manifold in order to perform the manifold synthesis. Despite of the advantages(More)
The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine. CM 57373 and dl-fenfluramine administered orally caused a dose-related reduction of food consumption by food-deprived(More)
The pharmacological effects of two newly synthesized anorectic agents CM 57373 (4-amino-1-(6-bromopyrid-2-yl) piperidine hydrochloride) and CM 57493 (4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6 tetrahydrophyridine hydrochloride) have been studied. Both drugs decreased food intake dose dependently in rats deprived of food for 20 h/d. The doses that(More)
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