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UNLABELLED Attenuation correction (AC) of whole-body PET data in combined PET/MRI tomographs is expected to be a technical challenge. In this study, a potential solution based on a segmented attenuation map is proposed and evaluated in clinical PET/CT cases. METHODS Segmentation of the attenuation map into 4 classes (background, lungs, fat, and soft(More)
The aim of this paper is to develop a registration methodology in order to combine anatomical and functional information provided by thoracic/abdominal computed tomography (CT) and whole-body positron emission tomography (PET) images. The proposed procedure is based on the incorporation of prior anatomical information in an intensity-based nonrigid(More)
The combination of magnetic resonance imaging (MR) and positron emission tomography (PET) scanners can provide a powerful tool for clinical diagnosis and investigation. Among the challenges of developing a combined scanner, obtaining attenuation maps for PET reconstruction is of critical importance. This requires accounting for the presence of MR hardware(More)
PURPOSE A critical question in the development of combined MR/PET scanners is whether MR can provide the tissue attenuation data required for PET reconstruction. Unfortunately, MR images are often unable to encompass the entire patient. The resulting truncation in the transverse plane leads to incomplete attenuation maps, causing artifacts in the(More)
UNLABELLED Technologic specifications of recently introduced integrated PET/MR instrumentation, such as MR-based attenuation correction, may particularly affect brain imaging procedures. To evaluate the qualitative performance of PET/MR in clinical neuroimaging, we systematically compared results obtained with integrated PET/MR with conventional PET/CT in(More)
UNLABELLED Ultrashort-echo-time (UTE) sequences have been proposed in the past for MR-based attenuation correction of PET data, because of their ability to image cortical bone. In the present work we assessed the limitations of dual-echo UTE imaging for bone segmentation in head and neck imaging. Sequentially acquired MR and PET/CT clinical data were used(More)
BACKGROUND Magnetic resonance (MR)-based attenuation correction is a critical component of integrated positron emission tomography (PET)/MR scanners. It is generally achieved by segmenting MR images into tissue classes with known attenuation properties (e.g., bone, fat, soft tissue, lung, air). Ultra-short echo time (UTE) have been proposed in the past to(More)
A nonlinear surface registration algorithm of thoracic/abdo-minal structures segmented from CT and PET volumes is presented. The aim of this work is to develop a method that can provide an initial estimate of the elastic deformation between the images, so that MI-based techniques can be successfully applied. To perform the matching, a B-spline Free Form(More)
PURPOSE To investigate proton density (PD)-weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures. METHODS A rotating ultra-fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft-tissues. An inverse(More)
BACKGROUND Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) shows high potential for patients with oropharyngeal cancer. Dental implants can cause substantial artifacts in the oral cavity impairing diagnostic accuracy. Therefore, we evaluated new MRI sequences with multi-acquisition variable-resonance image combination (MAVRIC SL) in(More)