Learn More
Using immunoprecipitation, mass spectrometry, and western blot analysis we investigated cytosolic protein interactions of the schizophrenia susceptibility gene dysbindin in mammalian cells. We identified novel interactions with members of the exocyst, dynactin and chaperonin containing T-complex protein complexes, and we confirmed interactions reported(More)
Reusing existing library components is essential for reducing the cost of software development and maintenance. When library components evolve to accommodate new feature requests, to fix bugs, or to meet new standards, the clients of software libraries often need to make corresponding changes to correctly use the updated libraries. Existing API usage(More)
—Programmers often need to reason about how a program evolved between two or more program versions. Reasoning about program changes is challenging as there is a significant gap between how programmers think about changes and how existing program differencing tools represent such changes. For example, even though modification of a locking protocol is(More)
The mRNA encoding the human low density lipoprotein (LDL) receptor is transiently stabilized after phorbol ester treatment of HepG2 cells and has been shown to associate with components of the cytoskeleton in this cell line (G. M. Wilson, E. A. Roberts, and R. G. Deeley, J. Lipid Res. 1997. 38: 437-446). Using an episomal expression system, fragments of the(More)
This study investigated the roles of endotoxemia and heat-induced tissue damage in the pathology of heat stroke. In groups of eight, male Wistar rats were treated with heat exposure only (HE), or heat exposure with turpentine (T+HE), dexamethasone (D+HE), and turpentine and dexamethasone combined (TD+HE). The rats remained sedated for 2 h after receiving(More)
The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in health and disease. In this study, we build upon our HuGX ('high-throughput(More)
A programme of general professional training in medicine based on the Royal Commission report has been in operation at the Western Infirmary, Glasgow, and associated hospitals since 1969. It involves a two-year rotation through general medicine, dermatology, psychiatry, paediatrics, geriatrics, and a variety of medical specialties. A third year is spent as(More)
  • 1