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The Frank-Starling relationship generally has been examined with filling pressure as the index of preload, resulting in a curvilinear function that plateaus at higher filling pressures. To investigate this relationship further in the intact heart, 32 dogs were chronically instrumented with left ventricular and pleural micromanometers and with regional (10(More)
Most recent reviews of pyogenic hepatic abscess emphasize percutaneous versus open surgical management and devote little time to studying the etiology or the clinical condition of the patient. In this study a detailed review was performed with a computerized analysis of multiple clinical parameters in 73 patients treated for pyogenic hepatic abscess during(More)
As processor performance continues to improve, more emphasis must be placed on the performance of the memory system. In this paper, a detailed characterization of data cache behavior for individual load instructions is given. We show that by selectively applying cache line allocation according the characteristics of individual load instructions, overall(More)
The diierence in processor and main memory cycle time has necessitated the use of aggressive prefetching techniques to reduce or hide main memory access latency. However, prefetching can signiicantly increase memory bandwidth and unsuccessful prefetches may even pollute the primary cache. Although the current metrics, coverage and accuracy, do provide an(More)
As processors continue to exploit more instruction-level parallelism, a greater demand is placed on reducing the effects of memory access latency. In this paper, we introduce a novel modification of the processor pipeline called memory renaming. Memory renaming applies register access techniques to load instructions, reducing the effect of delays caused by(More)
Highly aggressive multi-issue processor designs of the past few years and projections for the decade, require that we redesign the operation of the cache memory system. The number of instructions that must be processed (including incorrectly predicted ones) will approach 16 or more per cycle. Since memory operations account for about a third of all(More)
Very small instruction caches have been shown to greatly reduce fetch energy. However, for many appli- cations the use of a small filter cache can lead to an unacceptable increase in execution time. In this paper, we propose the Tagless Hit Instruction Cache (TH-IC), a technique for completely eliminating the performance penalty associated with filter(More)
A growing number of studies have explored the use of trace caches as a mechanism to increase instruction fetch bandwidth. The trace cache is a memory structure that stores statically non-contiguous but dynamically adjacent instructions in contiguous memory locations. When coupled with an aggressive trace or multiple branch predictor, it can fetch multiple(More)
In nine conscious, chronically instrumented dogs, ultrasonic dimension transducers measured left ventricular anterior-posterior and septal-free wall minor axis and major axis diameters. Matched micromanometers measured right and left ventricular transmural and transeptal pressures. Ventricular pressures and volumes were varied by inflation of implanted vena(More)
Ventilation with positive end-expiratory pressure (PEEP) is associated with reduced cardiac output, but the mechanisms involved are controversial. Possible explanations include increased intrathoracic pressure, reflex changes in myocardial inotropism, pulmonary vascular obstruction and abnormal ventricular interaction. Three types of conscious canine(More)