Gary S. Christensen

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Increased myocardial expression of preproendothelin-1 (ppET-1) mRNA has been associated with congestive heart failure (CHF) in rats. However, the time course and isoform pattern of ppET mRNA induction and the cellular localization of ET in failing hearts are unknown. Thus our aim was to investigate myocardial ppET mRNA expression in CHF rats during the(More)
OBJECTIVES Plasma endothelin (ET) concentrations are increased in heart failure. The aims of the present study were to investigate to what extent cardiac ET mRNA expression is induced in ischemic heart failure and whether there may be compensatory downregulation of myocardial mRNA levels for the ETA and ETB receptor subtypes. METHODS In rats with ischemic(More)
The effects of alpha- and beta-adrenergic stimulation on release of atrial natriuretic factor (ANF) were examined in seven anesthetized, open-chest pigs. The alpha-adrenergic agonist phenylephrine (28.0 micrograms/min) and the beta-adrenergic agonist isoproterenol (0.3 micrograms/min) were infused into the proximal part of the circumflex coronary artery to(More)
Network Systems' Hyperchannel* is a 50M-bps local area network that includes both hardware and software components. In the local area, Hyperchannel uses a baseband, multidrop coaxial cable (coax), and various adapter models provide a matching data channel or DMA interface to a wide range of mainframes, main-frame peripheral subsystems, and minicomputers.(More)
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