Gary R. Mayer

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ACCEPTED BY THE GRADUATE COLLEGE iii ABSTRACT Simulation modeling offers important and unique capabilities for analysis and design of service-oriented computing systems that must satisfy multiple, competing Qualities of Service (QoS) requirements. In order to aid design of service-based software systems (SBS), it is important to employ a suitable modeling(More)
We profiled receptor tyrosine kinase pathway activation and key gene mutations in eight human lung tumor cell lines and 50 human lung tumor tissue samples to define molecular pathways. A panel of eight kinase inhibitors was used to determine whether blocking pathway activation affected the tumor cell growth. The HER1 pathway in HER1 mutant cell lines HCC827(More)
Nm23 has been identified as a gene family encoding different isoforms of the nucleoside diphosphate kinase. This protein is a key enzyme in the control of cellular concentrations of nucleoside triphosphates. Moreover, it has been shown to play important roles in various cellular functions such as differentiation and metastasis. In the present study, a(More)
Hybrid agent-landscape models are used as an environment in which to study humans, the environment, and their dynamics. To provide flexibility in model design, expressiveness, and modification, the environment models and human agent models should be developed independently. While retaining each model's individuality, the models can be composed to create a(More)
Existing Cellular Automata formalisms do not consider heterogenous composition of models. Simulations that are grounded in a suitable modeling formalism offer unique benefits as compared with those that are developed using an ad-hoc combination of modeling concepts and implementation techniques. The emerging and extensive use of CA in simulating complex(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formulae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formu-lae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
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