Gary R. Mayer

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We profiled receptor tyrosine kinase pathway activation and key gene mutations in eight human lung tumor cell lines and 50 human lung tumor tissue samples to define molecular pathways. A panel of eight kinase inhibitors was used to determine whether blocking pathway activation affected the tumor cell growth. The HER1 pathway in HER1 mutant cell lines HCC827(More)
Hybrid agent-landscape models are used as an environment in which to study humans, the environment, and their dynamics. To provide flexibility in model design, expressiveness, and modification, the environment models and human agent models should be developed independently. While retaining each model's individuality, the models can be composed to create a(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formulae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
We isolated the gene amyE(TV1) from Thermoactinomyces vulgaris 94-2A encoding a nonglucogenic alpha-amylase (AmyTV1). A chromosomal DNA fragment of 2,247 bp contained an open reading frame of 483 codons, which was expressed in Escherichia coli and Bacillus subtilis. The deduced amino acid sequence of the AmyTV1 protein was confirmed by sequencing of several(More)
The Composable Cellular Automata (CCA) specification, introduced in a previous article, formally defines a system for building cellular automata models that can be composed with other models. The purpose is to build hybrid simulation models of large, complex systems with uniquely modeled subsystems. Multiple subsystems of a hybrid model may implement the(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formu-lae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
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