Gary R. Mayer

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We profiled receptor tyrosine kinase pathway activation and key gene mutations in eight human lung tumor cell lines and 50 human lung tumor tissue samples to define molecular pathways. A panel of eight kinase inhibitors was used to determine whether blocking pathway activation affected the tumor cell growth. The HER1 pathway in HER1 mutant cell lines HCC827(More)
ACCEPTED BY THE GRADUATE COLLEGE iii ABSTRACT Simulation modeling offers important and unique capabilities for analysis and design of service-oriented computing systems that must satisfy multiple, competing Qualities of Service (QoS) requirements. In order to aid design of service-based software systems (SBS), it is important to employ a suitable modeling(More)
Hybrid agent-landscape models are used as an environment in which to study humans, the environment, and their dynamics. To provide flexibility in model design, expressiveness, and modification, the environment models and human agent models should be developed independently. While retaining each model's individuality, the models can be composed to create a(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formulae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
The Composable Cellular Automata (CCA) specification, introduced in a previous article, formally defines a system for building cellular automata models that can be composed with other models. The purpose is to build hybrid simulation models of large, complex systems with uniquely modeled subsystems. Multiple subsystems of a hybrid model may implement the(More)
Security controls that comply with HIPAA security and privacy rules are available to mitigate the risks of Wireless Local Area Networks (WLAN). Controls are classified according to effectiveness in meeting HIPAA requirements. Content analysis on selected literature published from 2002 to 2004 was done to identify threats, vulnerabilities and controls that(More)
Many important scientific and engineering problems are studied using Cellular Automata (CA) models. Mathematical formu-lae with component-based modeling concepts are used to specify CA models. Computer simulation tools support viewing the dynamics of CA simulation models. Existing approaches with their tools are restrictive from visual model development(More)
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