Gary Nugent

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A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Following the delineation of structure-activity relationships in(More)
Families of 2-arylbenzotriazoles and 2-arylindazoles that show positive effects in screens predictive of endogenous utrophin upregulation have been identified. Synthesis and structure-activity relationships are described leading to compounds with attractive in vitro profiles.
Ewes were injected intramuscularly with 1 ml iodised oil at mating or during the first two months of pregnancy to determine if marginal iodine deficiency contributed to the high mortality of newborn lambs in Victoria. Iodine treatment markedly increased milk iodine concentration of ewes. In nine of ten trials conducted in 1979 and 1980 at Ararat, Hamilton,(More)
Computed tomography (CT) of the chest is an integral part of the staging of patients with oral cancer. It identifies metastases, synchronous pulmonary primaries, and detects small nodules of indeterminate character that require a follow-up scan. We aimed to find out how many patients with small nodules had had subsequent scans, and the outcome of those who(More)
further bone density scan continued to show an improved bone density when compared to the original diagnostic scan taken in 2004 and no further skeletal protection was recommended. Discontinuation of alendronate in cases of BRONJ can allow recovery of the physiological function of the jaw bone with time while still leaving a positive residual impact on(More)
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