Gary Nichols

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Micronised particles of revatropate hydrobromide were observed to agglomerate when stored in uncontrolled conditions. Dynamic vapour sorption (DVS), isothermal microcalorimetry, microscopy and particle size measurement by laser diffraction have been used to study micronised revatropate hydrobromide. The rate and extent of agglomeration were dependent on the(More)
BACKGROUND Acute postoperative pain causes physiological deficits and slows recovery. Reduction of such pain by local anesthetics that are delivered for several days postoperatively is a desirable clinical objective, which is approached by a new formulation and applied in animal studies reported here. METHODS We subcutaneously injected a new formulation(More)
The solid state dehydration of inosine dihydrate has been investigated using powder X-ray diffraction, differential scanning calorimetry, thermal gravimetric analysis, dynamic vapor sorption, hot stage microscopy, 13C solid state NMR, and variable temperature Fourier transform infrared spectroscopy. The information obtained from these experiments has been(More)
This paper describes a method for the laboratory-scale crystallization of the orthorhombic polymorph (form II) of paracetamol (acetaminophen) from solution. Its structure has been determined by single-crystal X-ray crystallography at 298 K (to confirm the results of data published in 1974) and at 123 K (to improve the overall accuracy of the structure(More)
The terms "agglomerate" and "aggregate" are widely used by powder technologists to describe assemblages of particles that are found in dry powders and powders in liquid suspensions. Each term has a specific meaning but, unfortunately, they are frequently interchanged at will and this has resulted in universal confusion. This confusion is perpetuated by(More)
Melting points and fusion enthalpies are predicted for a series of 81 compounds by combining experimental solubilities in a variety of solvents and analyzed according to the theory of mobile order and disorder (MOD) and using the total phase change entropy estimated by a group additivity method. The error associated in predicting melting points is dependent(More)
Minority carrier lifetimes in 0.55 eV band-gap GaInAsSb epitaxial layers that are double capped with GaSb or AlGaAsSb layers were determined using time-resolved photoluminescence. It was found that accumulation of electrons at the p-doped GaInAsSb/GaSb type-II interface contributes significantly to the interfacial recombination velocity S, which was(More)
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  • Gary Nichols
  • 2012
Cathodoluminescence (CL) analysis is a mature technique which utilises the light that is emitted from materials when they are bombarded with a beam of high energy electrons to produce spectra and spectral images of specimens. This technique is used routinely in many industries as a non-destructive way to investigate and characterise inorganic compounds,(More)
BACKGROUND AND OBJECTIVES Postoperative pain alters physiological functions and delays discharge. Perioperative local anesthetics are effective analgesics in the immediate 1- to 2-day postoperative period, but acute pain often lasts longer. The goal of this work was to develop a local anesthetic formulation adhering to an intraoperative implanted device(More)