Gary Mayer

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ACCEPTED BY THE GRADUATE COLLEGE iii ABSTRACT Simulation modeling offers important and unique capabilities for analysis and design of service-oriented computing systems that must satisfy multiple, competing Qualities of Service (QoS) requirements. In order to aid design of service-based software systems (SBS), it is important to employ a suitable modeling(More)
We profiled receptor tyrosine kinase pathway activation and key gene mutations in eight human lung tumor cell lines and 50 human lung tumor tissue samples to define molecular pathways. A panel of eight kinase inhibitors was used to determine whether blocking pathway activation affected the tumor cell growth. The HER1 pathway in HER1 mutant cell lines HCC827(More)
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