Gary M. Pigeau

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Exocytosis of secretory vesicles results in the release of insulin from pancreatic β-cells, although little is known about this process in humans. We examined the exocytosis of single secretory vesicles and their associated fusion pores in human β-cells by cell-attached capacitance and conductance measurement. Unitary capacitance steps were observed,(More)
OBJECTIVE Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in beta-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor-activated PI3K isoforms is largely unexplored. We therefore investigated the role of the G-protein-coupled PI3Kgamma and its(More)
OBJECTIVE—Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in -cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor–activated PI3K isoforms is largely unexplored. We therefore investigated the role of the G-protein–coupled PI3K and its catalytic(More)
1 University of Alberta, Department of Pharmacology and the Alberta Diabetes Institute, Edmonton, Alberta, Canada 2 University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, United Kingdom 3 Merck Serono, Geneva Research Center, Geneva, Switzerland 4 University of Toronto, Department of Medicine, Medical Biophysics,(More)
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