Gary M. Pigeau

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Exocytosis of secretory vesicles results in the release of insulin from pancreatic beta-cells, although little is known about this process in humans. We examined the exocytosis of single secretory vesicles and their associated fusion pores in human beta-cells by cell-attached capacitance and conductance measurement. Unitary capacitance steps were observed,(More)
1 OBJECTIVE—Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in ␤-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor–activated PI3K isoforms is largely unexplored. We therefore investigated the role of the G-protein– coupled PI3K␥ and its catalytic(More)
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